Solutions | TransMed Systems

By: Xb Transmed  09-12-2011
Keywords: Health Sciences

The XB Bio-Integration Suite represents a complete analytical and data management solution for health sciences researchers and clinicians with several key capabilities:

Integrate All Data

Integrated Research Platform

Utilizing XB Bio-Integration Suite™, researchers are able to access multi-variant data sources (both internal to the organization and external public data stores), create unique patient cohorts, analyze the data utilizing a broad spectrum of analytic and statistical tools, and create unique, testable hypotheses. A spoke-level data mart is developed for the researcher, where he is able to integrate his data with the organization's hub data warehouse, creating a data mart unique to his study. After the completion of the study, the information the researcher gathered from the primary care providers as well as the ultrasound images is then merged back into the hub with appropriate enterprise data standards and metadata, where it can be leveraged by other researchers looking for similar information. The data is managed by the appropriate security services so that it is only utilized for the use cases approved by the IRB, even when brought into the hub.

Personalized Medicine Module

TMS offers a Personalized Medicine Module (PMM) as a component-off-the-shelf (COTS) add-on to XB-BIS. PMM leverages XB-BIS to generate a personalized medicine report, which identifies molecularly targeted therapies based upon the unique molecular profile of a patient's cancer. The report correlates molecular characteristics of the patient's disease with potential drug therapies. The module leverages multiple algorithms and the results are merged and ranked for the oncologist's consideration. Following are the steps for producing a personalized medicine report:

  • Physician consults with an eligible patient and presents the personalized medicine report as an option.
  • The physician's office collects key data on the patient's specific disease.
  • Patient undergoes a tumor procedure as part of standard-of-care pathology practices to acquire a fresh tumor sample.
  • A small portion of the tumor sample is sent to a designated CLIA lab for analysis.
  • The lab processes the sample to develop a complete genomic signature of the patient's unique cancer.
  • XB-BIS processes the gene expression data and analyzes the patient's information using a series of algorithms to identify key drug targets or signatures of drug response/resistance.
  • The patient's unique profile is then interrogated against molecularly targeted drug databases to align molecular characteristics of the patient's disease with potential therapeutic interventions.
  • XB-BIS invokes the MedTrust® oncology information service to search for related scientific and clinical evidence (publications, trials and research).
  • XB-BIS generates the Personalized Medicine Report and delivers it to the physician through a secure website.
  • Physician reviews the report to assist in developing an informed treatment plan with the patient.

Self-Service Cohort Identification

One of XB-BIS' main strengths is its ease of use. Researchers and clinicians are not required to learn SQL or other programming languages in order to perform complex queries and basic analysis. XB-BIS provides a simple and intuitive user experience for querying and viewing data. TMS presents XB-BIS' cohort identification features in a series of vignettes—starting simple and progressively becoming more complex. Imagine a researcher interested in identifying and evaluating mesothelioma patients and the detection of tumor markers at various stages based upon age of patient, race and ethnicity. The researcher can quickly and easily utilize the self-service cohort identification application to identify the number of consented patients and tumors in the biorepository, and then further refine the analysis set based on queried phenotype and molecular data across all time. Utilizing the cohort identification application, sequence and relative duration between events (key input to identifying members of the cohort) are easily provided to the researcher.

Keywords: Health Sciences

Other products and services from Xb Transmed


Software Architecture | TransMed Systems

The XB server application is hosted by Microsoft's Internet Information Server and communicates with the client via .NET Remoting over HTTP. Integration with other data services, such as Oracle EHA, is provided on this tier by customized extract/transform/load applications. Winform is typically deployed in a Citrix or Terminal Services as a remote application to centralize and manage deployment.


Features and Functions | TransMed Systems

XB Bio-Integration Suite includes many standard statistical and graphical tools for analysis such as t-tests, Chi squared tests, Mann Whitney tests, Wilcoxon tests, ANOVA tests, and Kappa Meyer graphics and clustergrams of related data. One of the key features of XB Bio-Integration Suite™ is its ability to generate probable hypotheses explaining correlations between sample sets for later validation within the laboratory.


Products | TransMed Systems

Our flagship product is the XB Bio-Integration Suite, a complete, fully integrated biological and medical informatics solution for translational research, designed to accelerate the discovery and implementation of molecular-based preventative, diagnostic, and therapeutic approaches to medicine.


Scientific Overview | TransMed Systems

We believe that in the future, patients will be assessed for their risk of developing a disease, accurately diagnosed at an early point after disease initiation, and then treated with "personalized" therapies based upon the specific genomic and phenotypic makeup of both the patient and his diseased tissue.