Software Architecture | TransMed Systems

By: Xb Transmed  09-12-2011

XB Bio-Integration Suite™ is currently built upon open standards-based Microsoft® technologies with an intuitive, Windows-based graphical user interface for immediate application in the lab. XB employs a three-tier architecture, built on the Microsoft .NET framework, as shown in figure 1 below. The XB client application is a "rich" WinForms program installed on the user's desktop computer. Alternatively, the client may be installed on a terminal server and accessed via remote desktop in order to simplify deployment. The XB server application is hosted by Microsoft's Internet Information Server (IIS) and communicates with the client via .NET Remoting over HTTP. Windows authentication is employed to prevent unauthorized access to the server. Both Oracle 11g and Microsoft SQL server relational databases are supported in the data tier. Integration with other data services, such as Oracle EHA, is provided on this tier by customized extract/transform/load (ETL) applications.

Figure 1: XB-BIS architecture

This 3-tier architecture provides offer numerous benefits, including:

Client Tier

  • Rich Winform user experience for interactive graphics
  • High performance with large data sets
  • Winform is typically deployed in a Citrix or Terminal Services as a remote application to centralize and manage deployment
  • Import/export data from the client
  • All client communication is through the application tie

Application Tier

  • Open SOA architecture
  • 90% of the services are stateless for ease of maintenance and scalability
  • Statistical computations and algorithms are performed on the application tier
  • Extensible; able to plug in other statistical libraries
  • Uses Windows authentication so users can use their existing domain user accounts—single sign-on

Data Tier

  • Deploy using SQL server 2008 or Oracle 11g
  • Research data is protected using domain controller groups

Other products and services from Xb Transmed


Features and Functions | TransMed Systems

XB Bio-Integration Suite includes many standard statistical and graphical tools for analysis such as t-tests, Chi squared tests, Mann Whitney tests, Wilcoxon tests, ANOVA tests, and Kappa Meyer graphics and clustergrams of related data. One of the key features of XB Bio-Integration Suite™ is its ability to generate probable hypotheses explaining correlations between sample sets for later validation within the laboratory.


Solutions | TransMed Systems

Utilizing XB Bio-Integration Suite™, researchers are able to access multi-variant data sources, create unique patient cohorts, analyze the data utilizing a broad spectrum of analytic and statistical tools, and create unique, testable hypotheses. A spoke-level data mart is developed for the researcher, where he is able to integrate his data with the organization's hub data warehouse, creating a data mart unique to his study.


Products | TransMed Systems

Our flagship product is the XB Bio-Integration Suite, a complete, fully integrated biological and medical informatics solution for translational research, designed to accelerate the discovery and implementation of molecular-based preventative, diagnostic, and therapeutic approaches to medicine.


Scientific Overview | TransMed Systems

We believe that in the future, patients will be assessed for their risk of developing a disease, accurately diagnosed at an early point after disease initiation, and then treated with "personalized" therapies based upon the specific genomic and phenotypic makeup of both the patient and his diseased tissue.