Clemex PSA - Particle Size and Shape
Image Analysis Workstation
Addressing a need in the field of particle characterization,
the Clemex Particle Size System is a versatile
particle size and particle shape analysis tool that
can be used in a wide range of applications in the
pharmaceutical industries and material science.
Clemex PSA300 - Lab Unit
The Lab Unit is a self-contained automated
image analysis solution that combines Clemex's powerful particle characterization
software with an automated microscope and high resolution camera.
It is a turnkey solution for labs that want to maintain an analytical microscopy
environment with minimum intervention by the operator yet still yield maximum
detail in the results.
Clemex PSA - Research Unit
The Clemex Particle Size System Research Unit is a more traditional microscopy solution. It
is a highly integrated system that combines image analysis software, up to two
digital cameras (for example, color and monochrome), a microscope, a high-performance
PC, a motorized x/y/z stage, and has the flexibility of adjusting parameters
(such as various light filters). This system has been designed to serve the scientist
that must analyze various samples and, according to the best optical settings,
develop methods of analysis for each one.
Image Analysis by Microscopy
Recently, the use of microscopy
and image analysis is increasingly being recognized
as the most reliable technique to characterize particle
shape and characterize a particle size and volume distribution.
Traditional methods, such as laser diffraction, although
highly efficient, give limited information on particle
shape proving image analysis as the best tool for performing
Original gray image
Outline of detected particles
Industry experts, especially pharmaceutical, are now looking to characterize
particle shape in addition to particle size, to gain a better understanding of
how shape can effect the various properties of a product. More are recognizing
the significance of particle size and shape as well as their impact on the physical
characteristics of many particulate materials. Process problems with drug substances
can often be attributed to the particle size or shape of the active material. The ability to accurately analyze and characterize particle by
image analysis can significantly improve your company’s manufacturing efficiency.
It can also improve product performance for maximum effectiveness.
Crossed Fibers Algorithm
A unique algorithm to improve accuracy when defining the length and shape of fibers. Older algorithms would define crossed fibers as either an x-shaped particle, or break the fibers into four or five segments. Using this new algorithm, the PSA300 separates crossing fibers as individual particles and assigns each one accurate size and shape parameters. This is the first image analysis system capable of proper characterization of fibers or elongated crystals, a very important control issue in the pharmaceutical industry.
Identyfied Cross Fibers
Clemex Particle Size System provides true
particle shape information. Information is not determined
by “correction factors” rather it is
based on exactly what is seen in the microscope.
Measurements are possible for individual or mixtures
of different textured particles (opaque, semi-transparent,
Real Volume vs. Spherical Volume
Clemex Particle Size System automatically calculates various measurements simultaneously on thousands of individual particles. It is capable of generating statistically significant results in an amazingly short time. The powerful report generator allows speedy data processing and flexible reporting capabilities.
Clemex Particle Size System allows the management of user rights, audit trail of critical interventions, electronic signatures as well as overwrite protection of all electronic documents produced by Clemex Particle Size System imaging workstation (images, stage patterns, image analysis routines, raw binary data, image analysis report in PDF). Traceability is assured by saving all analysis settings, data, results, and images (if required) in the same protected file. All of these security features are designed to conform to regulatory requirements such as FDA 21 CFR part 11 ensuring data integrity.