NOBIVAC LYME - Mechanism of Action

By: Intervet  09-12-2011

Nobivac® Lyme was specifically designed to target two key factors involved in the transmission of Lyme disease—OspA and OspC.1

Nobivac® Lyme combines 2 isolates of Borrelia burgdorferi.

  • Isolate 1 is a traditional B. burgdorferi isolate that stimulates production of borreliacidal antibodies* to outer surface protein A (OspA).
  • Isolate 2 is a unique isolate that stimulates the production of borreliacidal antibodies to outer surface protein C (OspC).1

Because it is made up of these 2 isolates, Nobivac® Lyme provides additional defense against B. burgdorferi infection in dogs.

The ability to target both OspA and OspC is critical to preventing transmission of B. burgdorferi from an infected tick to the dog.

OspA borreliacidal antibodies can only kill Borrelia in the feeding tick.

 

OspC borreliacidal antibodies can kill Borrelia in the tick and in the dog.

  

Reference:
1. LaFleur RL, Dant JC, Wasmoen TL, et al. Bacterin that induces anti-OspA and anti-OspC borreliacidal antibodies provides a high level of protection against canine Lyme disease. Clin Vaccine Immunol. 2009;16:253–259.


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09-12-2011

NOBIVAC LYME - Safety

Client-owned dogs were vaccinated subcutaneously with a 1-mL dose of Nobivac® Lyme and boosted with an additional 1-mL dose 21 days later, for a total of 1,236 vaccine administrations. Mild, transient soft tissue swelling, which may occur at the injection site, is a typical response following subcutaneous vaccination with a whole-cell bacterin.


09-12-2011

NOBIVAC LYME - Efficacy

LaFleur RL, Dant JC, Wasmoen TL, et al. Bacterin that induces anti-OspA and anti-OspC borreliacidal antibodies provides a high level of protection against canine Lyme disease. 15 vaccinates and 15 controls received either Nobivac® Lyme or a placebo injection administered subcutaneously on Days 0 and 21. Nobivac® Lyme has been shown to produce borreliacidal antibodies that are highly effective in killing Borrelia burgdorferi.1.


09-12-2011

NOBIVAC LYME - Overview

Nobivac® Lyme is a bacterin that contains two inactivated strains of Borrelia burgdorferi comprised of outer surface protein A and outer surface protein C. This bacterin is approved for the vaccination of healthy dogs as an aid in the prevention of subclinical arthritis caused by B. burgdorferi. Lyme is administered subcutaneously as an initial vaccination followed by a booster 2 to 4 weeks later.


09-12-2011

NOBIVAC LYME - Lyme Disease Transmission

Soon after the tick takes its bloodmeal, OspA expression decreases and OspC expression increases, becoming the dominant outer surface protein. When a Borrelia-infected tick attaches to a dog, high levels of OspA are expressed by the Borrelia, which are residing in the tick’s midgut. Burgdorferi have different outer surface proteins that act as antigens and are expressed at various phases in the tick feeding cycle.