NOBIVAC LYME - Efficacy

By: Intervet  09-12-2011
Keywords: Dogs

Nobivac® Lyme has been shown to produce borreliacidal antibodies that are highly effective in killing Borrelia burgdorferi.1

In a tick challenge study:

  • 30 8-week old puppies were randomly assigned to two groups
  • 15 vaccinates and 15 controls received either Nobivac® Lyme or a placebo injection administered subcutaneously on Days 0 and 21
  • All dogs were challenged with live B. burgdorferi–infected ticks 3 weeks after the second dose
  • Ticks fed for 7 days, then were examined for B. burgdorferi
  • Evaluations in dogs included skin biopsies, joint tissue analyses, and assessment for clinical signs of disease

 

Nobivac® Lyme has also been shown to help prevent Lyme disease–associated joint abnormalities.1

Nobivac® Lyme helps prevent subclinical and clinical signs of illness due to Lyme disease.1

In dogs vaccinated with Nobivac® Lyme…

  • No B. burgdorferi were recovered from joint tissues
  • No inflammatory changes were seen in joint capsules 
  • No limb or joint disorders attributable to B. burgdorferi occurred 
  • No serologic evidence of exposure to B. burgdorferi was present

In control dogs…

  • 14 out of 15 had antibodies specific for B. burgdorferi
  • 10 out of 15 developed joint stiffness or lameness, or chronic joint inflammation (synovitis) 
  • 8 out of 15 had isolation of B. burgdorferi from the joint
Reference:

1. LaFleur RL, Dant JC, Wasmoen TL, et al. Bacterin that induces anti-OspA and anti-OspC borreliacidal antibodies provides a high level of protection against canine Lyme disease. Clin Vaccine Immunol. 2009;16(2):253–259.

Keywords: Dogs

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NOBIVAC LYME - Safety

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