21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function
Cheryl Millett Omega 3 & Holistic Nutritionist
Sports Nutrition, Fatty Acids, Essential Fatty Acids
21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function and performance in male athletes compared to olive oil placebo
Evan J. H. Lewis, Peter W. Radonic, Thomas M. S. Wolever and Greg D. Wells (Journal of the International Society of Sports Nutrition JISSN research link) and (US National Library of Medicine PubMed research link)
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In conclusion, 21-days of N-3 PUFA supplementation increased plasma EPA N-3 PUFA concentration. Neuromuscular function was improved through increased muscle activation and sprint cycling performance was maintained from attenuated Wingate percent power drop. Our data provide a basis for further investigation of the effects of N-3 PUFA supplementation on the neuromuscular system and as an ergogenic aid for trained individuals.
Our data indicates N-3 PUFA supplementation improved peripheral neuromuscular function and aspects of fatigue with an unclear effect on central neuromuscular function. Clinical trial registration NCT0201433.
Omega-3 supplementations For 21-days, participants consumed 5 mL of seal oil N-3 PUFA (5000 mg N-3 PUFA, 375 mg EPA, 230 mg DPA, 510 mg DHA and with 1000 IU vitamin D3) (Auum Inc., Timmons, On) or 5 mL olive oil (Bertolli, Mississauga, Lewis et al. Journal of the International Society of Sports Nutrition (2015) 12:28 Page 4 of 11 Canada) with 1000 IU vitamin D added. Participants were instructed to take 2–2.5 mL servings orally twice daily, and to let the oil remain in the mouth for 1-min before swallowing to allow for sublingual absorption . Seal oil was chosen as the source of experimental N-3 supplement for this study because mammalian (seal) triacylglycerol molecules have N-3 PUFA fats primarily in the sn-1 and sn-3 positions, as opposed to the sn-2 position of fish oil N-3 PUFA [15, 16]. Fats in the sn-3 position are preferentially cleaved by sublingual lipases, and the sn-1 fat is cleaved in the small intestine, while the sn-2 fatty acid is left for later esterification [14, 17]. These structural differences are thought to enable chylomicrons and chylomicron remnants containing mammalian N-3 PUFA to have a higher rate of clearance from the blood compared to fish oil intake .
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