Nucro-Technics – GLP Toxicology Services

By: Nucro Technics  09-12-2011
Keywords: Pharmaceuticals, Medical Devices, Research Services

NUCRO-TECHNICS‘ long experience with regulatory guidelines and with a variety of therapeutic agents and industrial chemicals makes us the logical choice for your toxicology needs. NUCRO-TECHNICS offers comprehensive experience in pre-clinical and research services to determine the safety evaluation of substances for government agencies, as well as clients in the pharmaceutical, chemical, biotechnology, petroleum, and device industries.

Study protocols designed at NUCRO-TECHNICS comply with the requirements of Canadian, U.S. and international regulatory agencies including, but not limited to, Health Canada, the U.S. FDA, EPA and others. We also provide a wide variety of biological assays in accordance with the USP, EP, BP, and JP.

Our testing includes general mammalian toxicology and we can perform the full spectrum of acute, bioavailability / pharmacokinetic, subchronic, and chronic studies typically required for new pharmaceuticals and biotechnology products. In addition, we can test biomedical engineering products and medical devices in a variety of protocols. Protocol design, whenever possible, is based on regulatory requirements. Studies are performed in compliance with Good Laboratory Practices (GLPs) and/or Good Manufacturing Practices (GMPs).

NUCRO-TECHNICS also provides a broad spectrum of general and specialized Clinical Pathology Analysis, and specialized histological services for veterinary and industrial research. A variety of haematoxylin and eosin and special stain techniques for diagnostic pathology, as well as specialized histochemistry, immunohistochemistry, and autoradiography techniques are available for research purposes.

Validated LABCAT® software provides a reliable set of tools that automates data management throughout the various phases of different studies.

The following service offerings are available:

Acute Toxicity Studies
  • Acute toxicity test (all routes)
  • Dermal and Eye Irritation Studies
  • Dermal Sensitization (multiple methods available)
  • Vaginal Irritation Studies
  • PK/PD Studies
Subacute Toxicity Studies
  • Dose range-finding studies
  • 14-day toxicity studies: Repeated dermal and ocular studies
  • 28 and 90-day toxicity studies
Chronic Toxicity Studies
  • 6, 12, 18, and 24-month toxicity studies in rodents and canines
Other Studies
  • Cardiovascular, Respiratory, and CNS Safety Pharmacology
  • Assessment of Carcinogenicity in p53 +/- mice
Clinical Pathology Services
  • Clinical Chemistry
  • Coagulation Tests
  • Haematology
  • Parasitology
  • Urinalysis
  • Cytology
Histopathology Services
  • Immunohistochemistry
  • Paraffin Embedding
  • Microtomy
  • Staining
  • Microscopy
  • Photography

All work is done to the appropriate standards, and subjects are maintained according to the requirements of the Animals for Research Act (Ontario), the Guidelines of the Canadian Council on Animal Care (CCAC), and the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC).

Keywords: Acute Toxicity, Chronic Toxicity, Mammalian Toxicology, Medical Devices, Pharmaceuticals, Research Services, Toxicity Studies,

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