Effusivity - C-Therm - Thermal Conductivity Instruments

By: C-therm Technologies  09-12-2011
Keywords: Analytical Technology, Powder Blending,

C-Therm Technologies (formerly Mathis Instruments) in collaboration with major pharmaceutical companies, manufacturers of powder blending equipment, and the FDA, has developed a revolutionary tool to address this need – the ESP™ Pharmaceutical Blend Uniformity Monitoring System.

C-Therm effusivity sensors can differentiate between pharmaceutical ingredients based on their distinct thermal characteristics.

Evaluate, Monitor and Control Blend Uniformity On-line

Designed for a phased integration, the ESP™ networked sensors are engineered for retrofit installation on existing blending equipment.
Screen information generated by the ESP™ shows test results captured during a test at Patterson-Kelly using a 3 sensor version of the system.

Key Advantages of the ESP™

  • Non-destructive process – does not alter excipients or other ingredients
  • Eliminates thieving – does not compromise containment
  • Can be phased in – easy implementation in logical steps
  • Retrofittable – can be incorporated on existing blending equipment
  • Easy to clean and maintain
  • Increased production knowledge – provides valuable information about the blending process, including the detection of deblending
  • Accelerates formulation R&D and scale up, and improves ongoing production – a highly valuable troubleshooting tool
  • Accurate results – strong correlation with HPLC and other methods
  • Cost savings – reduces operating costs and lost revenue due to discarded batches
  • Reduced liability risk
  • Improved batch traceability
  • Offers manufacturers a viable way to address Process Analytical Technology (PAT)

Keywords: Analytical Technology, Powder Blending,

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