PRODUCTS & TECHNOLOGY:
nanoBioSciences, LLC has developed
the patented Advanced micro-needle Patch ( AdminPatch® )transdermal system allowing continuous delivery through the skin of
proteins and water-soluble drugs.
The AdminPatch® system is an advanced microneedle
transdermal delivery technology that painlessly and instantaneously forms
hundreds of tiny aqueous channels (‘micropores’) through the stratum corneum and
epidermis, the outer resistive surface layers of skin. Proteins and
water-soluble molecules can enter the body through these aqueous micropores for
either local effect, or by entering the circulation, for systemic effect. The
created aqueous channels stay constantly open while AdminPatch® is applied on the skin and, therefore, enable the rapid,
sustained, and efficient delivery of drugs through these aqueous channels formed
in the skin surface.
The AdminPatch® system is comprised of a single-use
Product and a re-useable handheld Applicator.
The disposable AdminPatch®
Product contains the proprietary AdminPatch® microneedle
array laminated on a conventional transdermal drug-in-adhesive patch.
is based on the proprietary microneedle shape which is developed by
nanoBioSciences LLC. First, the proprietary microneedle shape allows continuous
delivery of drugs when the microneedle is inserted in the skin. Second, the
microneedles are formed from a standard metal film which allows very robust and
inexpensive manufacturing of the AdminPatch™. Third, a conventional
transdermal drug-in-adhesive patch can be simply laminated on the back surface of
microneedle array .
The aqueous channels formed by the microneedles in the stratum
corneum using the AdminPatch® system have a depth of about 100-300
microns, sufficient to extend through the viable epidermis but shallow enough to
avoid blood capillaries located deeper the dermis and any pain receptors.
When the transdermal patch with microneedles is removed from the
skin, the micropores simply collapse and the skin barrier is quickly restored.
The painless AdminPatch® system combines effective delivery of
drugs through the skin with excellent skin sensation and cosmetics, is easy and
intuitive to use by patients and medical personnel alike, and can be
economically produced to scale using mature high-volume low-cost processes.