Antibody Cross-Reactivity

By: Wax-it Histology Services  16-08-2010
Keywords: Immunohistochemistry, Immunohistochemistry Services

Wax-it Histology Services offers both non-GLP and GLP-compliant Tissue Cross Reactivity Studies which permit researchers to investigate and validate that their antibody of interest does not bind to other epitopes other than the expected target site. Identification of such cross-reactivity in the discovery / pre-clinical stage of drug development can help to avoid adverse and unforeseen toxicological effects in future human clinical trials.

Wax-it Histology Services Inc. utilizes our in-house TissueMacroArray system to permit rapid screening of potential tissue cross-reactivity. These TissueMacroArrays incorporate multiple arrayed tissues from the same species into a single tissue block.* This provides for more consistent, reliable staining with immunohistochemistry techniques, as well as the benefit of significantly reduced costs for the sponsor as multiple tissues are stained on a single slide.

A comprehensive study program is offered to support our clients’ research needs, including:

  • Complete tissue banks of human, mouse, rat, and pig
  • Full medical history of human tissues
  • Study-specific protocols that reflect the sponsor’s requirements
  • Unparalleled expertise in immunohistochemistry, histology, immunopathology, and protocol development
  • Tissue analysis conducted by board-certified pathologists
  • Comprehensive, high-quality reports
  • Digital photomicroscopy and/or digital whole-slide scanning
  • Rapid turn-around times
  • Cost-effective pricing

Keywords: Immunohistochemistry, Immunohistochemistry Services

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