Estrosmart

By: Healthy Immunity  09-12-2011
Keywords: Cancer, breast cancer, Green Tea

ESTROSMART Balanced hormones, healthy breasts, endometriosis,
fibroids, effortless periods

What to expect from this product:
  • Maintains healthy estrogen to progesterone balance
  • Protects your breasts
  • Reduces and eliminates the occurrence of breast cysts
  • Detoxifies the liver of carcinogenic estrogens found in plastics, pesticides, cosmetics and more
  • Stops flooding, heavy, debilitating periods
  • Halts abnormal cell growth (fibroids, cysts, endometriosis)
  • For those with PCOS and ovarian cysts
  • Halts conversion of 2-hydroxyestrone metabolites to carcinogenic estrogens (16-hydroxyestrone)
  • Contains the equivalent cancer protecting plant nutrients as eating 1 kilo of cruciferous vegetables (broccoli, Brussels sprouts, etc..)
  • Eliminates PMS and makes periods effortless
  • Maintains healthy PAP smears
  • Eliminates hormonal acne
Take before menopause to ensure a healthy transition WHO NEEDS HORMONE BALANCING THERAPY?
All women but especially those with:
  • Exposure to pesticides, herbicides and toxins
  • Endometriosis
  • Fibrocystic breasts (benign breast disease)
  • Peri-menopause
  • Gallstones
  • Acne
  • Obesity or weight problems
  • Ovarian cysts
  • Uterine fibroids
  • Breast Cancer
  • Ovarian Cancer
  • PMS
  • Desire to prevent hormone dependent cancers

FORMULA EVERY 2 CAPSULES CONTAIN:
Calcium D-Glucarate 150 mg
Indole-3-Carbinol (plant sourced) 150 mg
Green Tea Extract
(30:1 from 3000 mg of Green Tea—caffeine free—80% Polyphenols) 100 mg
Turmeric (95% Curcumin) 50 mg
DIM (di-indolyImethane) 50 mg
Rosemary Extract (10:1 from 250 mg of Rosemary) (6% Carnosic Acid) 25 mg
Sulforaphane (from BroccophaneTM broccoli sprout Extract) 200 mcg

VEGAN FRIENDLY RECOMMENDED DOSAGE:

Adults (12 years and older):

2 capsules of ESTROSMART daily with food for prevention, hormonal acne, fibrocystic breasts, and to promote effortless periods and balances hormones, or as directed by a health practitioner.

4 capsules of ESTROSMART daily with food for endometriosis, fibroids, cysts, flooding periods, or as directed by a health practitioner.

Indole-3-carbinol

(I-3-C) is an anti-cancer phytonutrient found in cruciferous vegetables. Research has shown that I3C helps to breakdown cancer-causing estrogens to non-toxic forms. I3C maintains a healthy cervix, protects against HPV cervical lesions and controls abnormal cell growth found in those with uterine fibroids and endometriosis.

  • Stanley M. Chapter 17: Genital human papillomavirus infections--current and prospective therapies. J Natl Cancer Inst Monogr. 2003;(31):117-24.
  • Nachshon-Kedmi M, Yannai S, Haj A, Fares FA. Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol. 2003 Jun;41(6):745-52.
  • Nachshon-Kedmi M, Yannai S, Haj A, Fares FA. Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol. 2003 Jun;41(6):745-52.
  • Gao X, Petroff BK, Oluola O, Georg G, Terranova PF, Rozman KK. Endocrine disruption by indole-3-carbinol and tamoxifen: blockage of ovulation. Toxicol Appl Pharmacol. 2002 Sep 15;183(3):179-88.
  • Brignall MS. Prevention and treatment of cancer with indole-3-carbinol. Altern Med Rev. 2001 Dec;6(6):580-9.
  • Chen DZ, Qi M, Auborn KJ, Carter TH. Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. J Nutr. 2001 Dec;131(12):3294-302.
  • Riby JE, Feng C, Chang YC, Schaldach CM, Firestone GL, Bjeldanes LF. The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway. Biochemistry. 2000 Feb 8;39(5):910-8.
  • Osborne MP. Chemoprevention of breast cancer. Surg Clin North Am. 1999 Oct;79(5):1207-21.
  • Cover CM, Hsieh SJ, Cram EJ, Hong C, Riby JE, Bjeldanes LF, Firestone GL. Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells. Cancer Res. 1999 Mar 15;59(6):1244-51.
  • Suto A, Bradlow HL, Kubota T, Kitajima M, Wong GY, Osborne MP, Telang NT. Alteration in proliferative and endocrine responsiveness of human mammary carcinoma cells by prototypic tumor-suppressing agents. Steroids. 1993 May;58(5):215-9.
  • Gary J. Kelloff, James A. Crowell, Vernon E. Steele, Ronald A. Lubet, Winfred A. Malone, Charles W. Boone, Levy Kopelovich, Ernest T. Hawk, Ronald Lieberman, Julia A. Lawrence, Iqbal Ali, Jaye L. Viner and Caroline C. Sigman. Progress in Cancer Chemoprevention: Development of Diet-Derived Chemopreventive Agents. (Journal of Nutrition. 2000;130:467S-471S.)
  • Auborn KJ, Qi M, Yan XJ, Teichberg S, Chen D, Madaio MP, Chiorazzi N. Lifespan is prolonged in autoimmune-prone (NZB/NZW) F1 mice fed a diet supplemented with indole-3-carbinol. J Nutr. 2003 Nov;133(11):3610-3.
  • McAlindon TE, Gulin J, Chen T, Klug T, Lahita R, Nuite M. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus. 2001;10(11):779-83.
Calcium D-glucarate

is a powerful detoxifier of excess estrogens from the liver.

Green Tea Extract

contains polyphenols, catechins and flavonoids shown to be protective against estrogen related cancers.

  • Maryam R. Sartippour, Richard Pietras, et al. The combination of green tea and tamoxifen is effective against breast cancer. Carcinogenesis (2006) 27 (12): 2424-2433.
  • Zhang Q, Tang X, Lu Q, Zhang Z, Rao J, Le AD. Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells. Mol Cancer Ther. 2006 May;5(5):1227-38.
  • El-Beshbishy HA. Hepatoprotective effect of green tea (Camellia sinensis) extract against tamoxifen-induced liver injury in rats. J Biochem Mol Biol. 2005 Sep 30;38(5):563-70.
  • Fujiki H, Suganuma M, Kurusu M, Okabe S, Imayoshi Y, Taniguchi S, Yoshida T. New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen. Mutat Res. 2003 Feb-Mar;523-524:119-25.
  • Sartippour MR, Shao ZM, Heber D, Beatty P, Zhang L, Liu C, Ellis L, Liu W, Go VL, Brooks MN. Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. J Nutr. 2002 Aug;132(8):2307-11.
  • Sartippour MR, Heber D, Zhang L, Beatty P, Elashoff D, Elashoff R, Go VL, Brooks MN. Inhibition of fibroblast growth factors by green tea. Int J Oncol. 2002 Sep;21(3):487-91.
Curcumin

is the yellow pigment of turmeric—the chief ingredient in curry. It is a powerful anti-inflammatory agent and it works to inhibit all steps of cancer formation: initiation, promotion and progression. Curcumin also protects against inflammatory calcium loss from our bones.

  • S P Verma, B R Goldin, and P S Lin. The inhibition of the estrogenic effects of pesticides and environmental chemicals by curcumin and isoflavonoids. Environ Health Perspect. 1998 December; 106(12): 807-812.
  • Bachmeier B, Nerlich AG, Iancu CM, Cilli M, Schleicher E, Vene R, Dell'Eva R, Jochum M, Albini A, Pfeffer U. The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice. Cell Physiol Biochem. 2007;19(1-4):137-52.
  • Aggarwal BB, Banerjee S, Bharadwaj U, Sung B, Shishodia S, Sethi G. Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. Biochem Pharmacol. 2007 Apr 1;73(7):1024-32. Epub 2006 Dec 15.
  • Wahl H, Tan L, Griffith K, Choi M, Liu JR. Curcumin enhances Apo2L/TRAIL-induced apoptosis in chemoresistant ovarian cancer cells. Gynecol Oncol. 2007 Apr;105(1):104-12. Epub 2006 Dec 15.
  • Abas F, Hui LS, Ahmad S, Stanslas J, Israf DA, Shaari K, Lajis NH. Biological evaluation of curcumin and related diarylheptanoids. Z Naturforsch C. 2006 Sep-Oct;61(9-10):625-31.
  • Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res. 2005 Oct 15;11(20):7490-8.
  • Tathagata Choudhuri, Suman Pal, Tanya Das and Gaurisankar Sa. Curcumin Selectively Induces Apoptosis in Deregulated Cyclin D1-expressed Cells at G2 Phase of Cell Cycle in a p53-dependent Manner. May 20, 2005 The Journal of Biological Chemistry, 280, 20059-20068.
  • Di GH, Li HC, Shen ZZ, Shao ZM. [Analysis of anti-proliferation of curcumin on human breast cancer cells and its mechanism] Zhonghua Yi Xue Za Zhi. 2003 Oct 25;83(20):1764-8.
  • Conney AH. Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture. Cancer Res. 2003 Nov 1;63(21):7005-31.
  • Ramsewak RS, DeWitt DL, Nair MG. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomedicine. 2000 Jul;7(4):303-8.
  • T.Choudhuri. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Letters, Volume 512, Issue 1, Page 334.
  • Liontas A, Yeger H. Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma. Anticancer Res. 2004 Mar-Apr;24(2B):987-98.
  • Shao ZM, Shen ZZ, Liu CH, Sartippour MR, Go VL, Heber D, Nguyen M. Curcumin exerts multiple suppressive effects on human breast carcinoma cells. Int J Cancer. 2002 Mar 10;98(2):234-40.
  • Ramachandran C, Fonseca HB, Jhabvala P, Escalon EA, Melnick SJ. Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer Lett. 2002 Oct 8;184(1):1-6.
  • Mehta K, Pantazis P, McQueen T, Aggarwal BB. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs. 1997 Jun;8(5):470-81.
DIM

helps to break down cancer-causing estrogens to non-toxic forms. DIM is one of the products created by the breakdown of Indole-3-cardinol. ESTROSMART

TM

has always provided DIM but now we have added an additional 50mg.

    Rosemary Extract

    , a potent antioxidant, protects cells from cancer-causing agents, inhibits the growth of cancer cells and helps to detoxify carcinogenic estrogens.

    • Plouzek CA, Ciolino HP, Clarke R, Yeh GC. Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract. Eur J Cancer. 1999 Oct;35(10):1541-5.
    • Singletary K, MacDonald C, Wallig M. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett. 1996 Jun 24;104(1):43-8.
    • Sharabani H, Izumchenko E, Wang Q, Kreinin R, Steiner M, Barvish Z, Kafka M, Sharoni Y, Levy J, Uskokovic M, Studzinski GP, Danilenko M. Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia. Int J Cancer. 2006 Jun 15;118(12):3012-21.
    • Kosaka K, Yokoi T. Carnosic Acid, a Component of Rosemary (Rosmarinus officinalis L.), Promotes Synthesis of Nerve Growth Factor in T98G Human Glioblastoma Cells. 2003 Nov;26(11):1620-2.
    • Debersac P, Heydel JM, Amiot MJ, Goudonnet H, Artur Y, Suschetet M, Siess MH. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem Toxicol. 2001 Sep;39(9):907-18.
    • al-Sereiti MR, Abu-Amer KM, Sen P. Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J Exp Biol. 1999 Feb;37(2):124-30.
    • Okamura N, Haraguchi H, Hashimoto K, Yagi A. Flavonoids in Rosmarinus officinalis leaves. Phytochemistry. 1994 Nov;37(5):1463-6.
    Sulforaphane

    , from broccoli sprout extract, has been shown to stimulate the body's production of detoxification enzymes that eliminate xenoestrogens. Sulforaphane is also a powerful antioxidant.

    • Brian S. Cornblatt, Lingxiang Ye, Albena T. Dinkova-Kostova, Melanie Erb, Jed W. Fahey, Navin K. Singh, Min-Shue A. Chen, Tracey Stierer, Elizabeth Garrett-Mayer, Pedram Argani, Nancy E. Davidson, Paul Talalay, Thomas W. Kensler and Kala Visvanathan. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis (2007) 28 (7): 1485-1490.
    • Zhang Y, Talalay P, Cho CG, Posner GH. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci 1992;89:2399-403.
    • Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci 1997;94:10367-72.
    • Jed W. Fahey, Xavier Haristoy, Patrick M. Dolan et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. PNAS May 28, 2002 vol. 99 no. 11 7610-7615.
    • Verhoeven DT, Goldbohm RA, van Poppel G, et al. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem Biol Interact 1997;103:79-129 [review].
    • Verhoeven DT, Goldbohm RA, van Poppel G, et al. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev 1996;5:733-48 [review].
    • Talalay P, Zhang Y. Chemoprotection against cancer by isothiocyanates and glucosinolates. Biochem Soc Trans 1996;24:806-10.
    • Maheo K, Morel F, Langouet S, et al. Inhibition of cytochromes P-450 and induction of glutathione S- transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res 1997;57:3649-52.
    • Barcelo S, Gardiner JM, Gescher A, Chipman JK. CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Carcinogenesis 1996;17:277-82.
    • Plumb GW, Lambert N, Chambers SJ, et al. Are whole extracts and purified glucosinolates from cruciferous vegetables antioxidants? Free Radic Res 1996;25:75-86.
    • Nestle M. Broccoli sprouts in cancer prevention. Nutr Rev 1998;56:127-30 [review].
    • Fahey JW, Talalay P. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. Food Chem Toxicol 1999;37:973-9.
    • Jed W. Fahey, Xavier Haristoy, Patrick M. Dolan et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. PNAS May 28, 2002 vol. 99 no. 11 7610-7615.
    • Nestle M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci 1997;94:11149-51 [review].
    • Clapper ML, Szarka CE, Pfeiffer GR, et al. Preclinical and clinical evaluation of broccoli supplements as inducers of glutathione S-transferase activity. Clin Cancer Res 1997;3:25-30.
    • Nijhoff WA, Mulder TP, Verhagen H, et al. Effects of consumption of Brussels sprouts on plasma and urinary glutathione S-transferase class-alpha and -pi in humans. Carcinogenesis 1995;16:955-7.
    • Nestle M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci 1997;94:11149-51 [review].
    • Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett 1997;114:169-70.
    • Zhang Y, Callaway EC. High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J. 2002 May 15;364(Pt 1):301-7.
    • Kolm RH, Danielson UH, Zhang Y, Talalay P, Mannervik B. Isothiocyanates as substrates for human glutathione transferases: structure-activity studies. Biochem J. 1995 Oct 15;311 ( Pt 2):453-9.
    • Haristoy X, Angioi-Duprez K, Duprez A, Lozniewski A. Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in nude mice. Antimicrob Agents Chemother. 2003 December; 47(12): 3982-3984.
    • Frydoonfar HR, McGrath DR, Spigelman AD. Sulforaphane inhibits growth of a colon cancer cell line. Colorectal Dis. 2004 Jan;6(1):28-31
    • Gingras D, Gendron M, Boivin D, Moghrabi A, Theoret Y, Beliveau R. Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables. Cancer Lett. 2004 Jan 8;203(1):35-43.
    • Kim BR, Hu R, Keum YS, Hebbar V, Shen G, Nair SS, Kong AN. Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. Cancer Res. 2003 Nov 1;63(21):7520-5.
    • Jackson SJ, Singletary KW. Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor which disrupts tubulin polymerization. Carcinogenesis. 2003 Oct 24 [Epub ahead of print].
    • Solowiej E, Kasprzycka-Guttman T, Fiedor P, Rowinski W. Chemoprevention of cancerogenesis--the role of sulforaphane. Acta Pol Pharm. 2003 Jan-Feb;60(1):97-100.
    • Frydoonfar HR, McGrath DR, Spigelman AD. The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line. ANZ J Surg. 2003 Mar;73(3):154-6.
    LORNA VANDERHAEGHE HEALTH SOLUTIONS, INC.

    400 - 353 Water Street

    Vancouver, BC V6B 1B8

    TEL: 877-805-5353

    FAX: 877-805-5375

    Website:

Keywords: breast cancer, Cancer, Green Tea, Green Tea Extract, Tea Extract

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