Services of SynInnova Laboratories Inc., Canada

By: SynInnova Laboratories Inc.,  09-12-2011

Contract Research

SynInnova is a fully integrated chemistry service provider established to lessen the burden of drug development costs of pharmaceutical and biotech industries. We offer Ph.D. and M.S. level Full Time Equivalent (FTE) scientists who have extensive experience in broad spectrum of chemical synthesis. We gain our customers’ trust through our perseverance and strong commitment to quality, confidentiality and time lines.

In general, contract research can be conducted to develop synthesis of novel compounds, reagents or a new synthetic strategies. At SynInnova we continually do research to provide new synthetic methodologies, optimization of existing synthetic pathways and development of specialty reagents to maintain a competitive edge and improve cost efficiency for us and our customers.

We will conduct literature studies and conduct preliminary studies to determine feasibility of pertinent synthetic methods. If we mutually agree to pursue the project, a research agreement must be signed. One or more full-time chemists will be assigned to the project. Progress of the work is communicated at regular intervals, in written weekly or monthly reports. Samples of intermediate compounds are available on request at any stage of the synthesis. Final products will be shipped as per the customers’ request and transfer all the documentation to customers under strict confidentiality.

Custom Synthesis

Cost effective procedures are playing major role in R & D of the current drug development in spite of the growing demand for novel drugs in the market. Therefore there is an increasing demand for custom synthesis and that is why we are in the business. We take your pressures and create your dream products at the price you can afford. Our highly qualified scientific staff can handle any kind of projects prudently with in the committed timelines. With the track record of over 97% success rate, we assure you that you get charged only if we can deliver products up to your satisfaction.

Our most frequent custom synthesis requests are ready to use building blocks, tag molecules, intermediates, small molecules, reference compounds and novel reagents. Our highly qualified team has wide knowledge and experience of a variety of chemistry areas and has capabilities of synthesizing any challenging molecule in cost effective manner. Our expertise in aliphatic, aromatic, heterocyclic, boronic acid/ester, carbohydrate, and peptide chemistries help you to serve to make your desired products in the required quantities.

Our reaction capabilities include:

  • Alkylation
  • Amination
  • Amio Acids (natural & Unnatural)
  • Asymmetric synthesis
  • Carbonylation
  • Carbohydrates
  • Catalytic reductions
  • Cyanation
  • Dehydrogenation
  • Diels-Alder reaction
  • Friedel-Crafts reaction
  • Glycosylation
  • Grignard reaction
  • Halogenation
  • Hydrogenation
  • Formylation
  • Lithiation
  • Liquid ammonia reaction
  • Mannich reaction
  • Michael addition
  • Methylation
  • Nitration
  • Reductions
  • Reductive aminations
  • Oxidations
  • Suzuki coupling
  • Wolf-Kishner
  • Wittig Reaction

Medicinal Chemistry

As the industry is driving towards the cost effectiveness, it is very important to incorporate the best drug characteristics at the earliest possible stage which is achieved by lead optimization. In spite of advanced computer modelling programs, the limiting factor is still the generation of high quality compound libraries. At SynInnova our experienced team of medicinal chemists develop strategies tailored to clients needs taking ADME and toxicity issues into consideration to maximize results and minimize the time lines.

We offer the medicinal chemistry services at SynInnova to our customers to design and synthesis of novel compounds against a number of diseases of our customer’s interest. We provide the following services starting from a validated lead compound usually provided by the customer:

  1. Systematic SAR study
  2. Design of new analogues directed towards optimization of potency, selectivity and improvement of the ADME-Tox profile
  3. Consolidation of the IP position
  4. Analogue resynthesis/scale-up to support profiling studies
  5. Scaffold-hopping to identify new chemotypes

A constant communication with the customer's scientists (project management, chemists, biologists, toxicologists) insures the fast recognition of structure-activity relationships. Using parallel and/or convergent synthesis as well as traditional approaches, our scientists are able to synthesize quickly a significant variety of compounds.

Even in the early stages we design and synthesize compounds with improved pharmacokinetic (ADME) profiles: increased absorption, modified distribution, modulated sensitivity to metabolism and different elimination kinetics.

Process Development

A robust, reproducible and a scaleable process is often the deciding factor for any biologically active molecule to advance as an API. Essentially, the process must be absolutely safe. Our experienced and specially trained scale-up group develop cost effective and safe processes by eliminating expensive and toxic reagents. We will try to avoid chromatography wherever possible and minimise waste. Solvents will be chosen with regard to their residual effects and for new APIs we ensure ICH guidelines are followed.


For pharmaceutical applications, manufacturing of Active Pharmaceutical Ingredients (APIs) and intermediates is conducted under current Good Manufacturing Practices (cGMP) at FDA approved facilities. SynInnova offers a broad range of cGMP manufacturing services to pharmaceutical and biotech companies worldwide. Our manufacturing partner in India has facilities meet global regulatory requirement.

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Our compound libraries are designed to possess drug-like properties and they are created using innovative technologies along with traditional medicinal chemistry principles. We design unique compound libraries as advanced tools for drug discovery, enabling new generations of chemical entities.